RESUMO
Epigenomic imbalance drives abnormal transcriptional processes, promoting the onset and progression of cancer. Although defective gene regulation generally affects carcinogenesis and tumor suppression networks, tumor immunogenicity and immune cells involved in antitumor responses may also be affected by epigenomic changes, which may have significant implications for the development and application of epigenetic therapy, cancer immunotherapy, and their combinations. Herein, we focus on the impact of epigenetic regulation on tumor immune cell function and the role of key abnormal epigenetic processes, DNA methylation, histone post-translational modification, and chromatin structure in tumor immunogenicity, and introduce these epigenetic research methods. We emphasize the value of small-molecule inhibitors of epigenetic modulators in enhancing antitumor immune responses and discuss the challenges of developing treatment plans that combine epigenetic therapy and immunotherapy through the complex interaction between cancer epigenetics and cancer immunology.
RESUMO
PURPOSE: Use of three-dimensional finite element to analyze stress distribution and transient displacement of mandibular first molar both at the occlusal surface level, to investigate the biomechanical basis of vertical root fracture occurring in the mesial root. METHODS: Mimics finite element software was used to build the horizontal and tilt abrasion of the mandibular first permanent molar. Each status was then divided into 4 kinds of wearing degree and 8 models were then established including sliced 1, sliced 2, sliced 3, sliced 4 and miter 5°,miter10°,miter15°,miter20° respectively. 200 N of bite force was loaded on the occlusal surface using MSC. Marc nonlinear finite element analysis software was used to investigate the distribution of stress and transient displacement. RESULTS: When distal tipping angle of the abrasion plane of mandibular first molar increased from 5° to 15°, the angle between instant displacement contours and tooth long axis become smaller, the mesial root suffered from the biggest stress concentration and thus the possibility of longitudinal root fracture increased. CONCLUSIONS: When the abrasion plane of mandibular first molar tilted distally, the possibility of the mesial root longitudinal fracture increased.
